This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology.
SMAD4 is the common SMAD (co-SMAD)mediator of signal transduction by TGF-beta (transforming growth factor). It promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. It may act as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: deleted in pancreatic carcinoma locus 4; Deletion target in pancreatic carcinoma 4; DPC4; MAD homolog 4; MADH4; Mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; SMAD 4; SMAD family member 4; SMAD, mothers against DPP homolog 4; SMAD4
Gene Aliases: DPC4; JIP; MADH4; MYHRS; SMAD4
UniProt ID: (Human) Q13485
Entrez Gene ID: (Human) 4089