Immunogen sequence: PLSPNSPYPP SPASSTYPNS PASSGPGSPF QLPADTPPPA YMPPDDQMGQ DNSQPMDTSN NMIPQIMPSI SSRDVQPVAY EEPKHWCSIV YYELNNRVGE AFHASSTSVL VDGFTDPSNN KSRFCLGLLS NVNRNSTIEN TRRHIGKGVH LYYVGGEVYA ECLSDSSIFV QSRNCNFHHG FHPTTVCKIP SSCSLKIFNN QEFAQLLAQS VNHGFEAVYE LTKMCTIRMS FVKGWGAEYH RQDVTSTPCW IEIHLHGPLQ WLDKVLTQMG SPLNPISSVS; Positive Samples: SKOV3, MCF-7, Mouse kidney; Cellular Location: Cytoplasm, Nucleus
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD5 is required for normal development of the cardiovascular system in vivo; lack of the SMAD5 gene results in apoptosis of cardiac myocytes. 3 Upregulation of SMAD5 has been reported to mediate apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. Tissue specificity: Ubiquitous.
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Protein Aliases: Dwarfin-C; Dwf-C; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; mothers against DPP homolog 5; mSmad5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5
Gene Aliases: 1110051M15Rik; AI451355; Dwf-C; DWFC; JV5-1; MADH5; Msmad5; MusMLP; SMAD5
Molecular Function: transcription factor