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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide region of human MADH6.|
|Storage buffer||PBS with 2% sucrose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
|Western Blot (WB)||0.5-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24467 detects Smad6 in Human samples.
PA1-24467 has been successfully used in Western Blot and immunohistochemistry (paraffin) procedures.
PA1-24467 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human MADH6.
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HsT17432; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; SMAD 6; SMAD family member 6; SMAD, mothers against DPP homolog 6
AOVD2; HsT17432; MADH6; MADH7; SMAD6