Immunogen sequence: PTVCCNPYHF SRLCGPESPP PPYSRLSPRD EYKPLDLSDS TLSYTETEAT NSLITAPGEF SDASMSPDAT KPSHWCSVAY WEHRTRVGRL YAVYDQAVSI FYDLPQGSGF CLGQLNLEQR SESVRRTRSK IGFGILLSKE PDGVWAYNRG EHPIFVNSPT LDAPGGRALV VRKVPPGYSI KVFDFERSGL QHAPEPDAAD GPYDPNSVRI SFAKGWGPCY SRQFITSCPC WLEILLNNPR; Positive Samples: 22Rv1, Mouse heart, Rat brain; Cellular Location: Nucleus
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila and apos;mothers against decapentaplegic and apos; (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.
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Protein Aliases: MAD homolog 6; Mad homolog 7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; mothers against DPP homolog 6; SMAD 6; SMAD family member 6; SMAD, mothers against DPP homolog 6
Gene Aliases: AOVD2; b2b390Clo; HsT17432; MADH6; MADH7; Msmad6; SMAD6
Molecular Function: transcription factor