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Invitrogen

SMAD6 Polyclonal Antibody

View all (18) SMAD6 antibodies

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SMAD6 Polyclonal Antibody

Product Details

PA5-99401

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SMAD6(Accession O43541), corresponding to amino acid residues Q352-A402.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818334

Product Specific Information

Antibody detects endogenous levels of total SMAD6.

Target Information

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MAD homolog 6; Mad homolog 7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; mothers against DPP homolog 6; SMAD; SMAD 6; SMAD family member; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6

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Gene Aliases: AOVD2; b2b390Clo; HsT17432; MADH6; MADH7; Msmad6; SMAD6

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UniProt ID: (Human) O43541, (Mouse) O35182

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Entrez Gene ID: (Human) 4091, (Mouse) 17130

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Function(s)
transcription regulatory region sequence-specific DNA binding chromatin binding protein binding ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding metal ion binding co-SMAD binding I-SMAD binding R-SMAD binding activin receptor binding type I activin receptor binding protein sequestering activity transcription regulator inhibitor activity RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity transcription regulatory region DNA binding DNA-binding transcription factor gene-specific transcriptional regulator
Process(es)
ureteric bud development outflow tract septum morphogenesis heart valve development aortic valve morphogenesis mitral valve morphogenesis pulmonary valve morphogenesis ventricular septum development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter immune response zygotic specification of dorsal/ventral axis negative regulation of cell proliferation anatomical structure morphogenesis cell differentiation negative regulation of ossification BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway cell-substrate adhesion response to lipopolysaccharide negative regulation of activin receptor signaling pathway response to laminar fluid shear stress aorta development negative regulation of apoptotic process response to estrogen fat cell differentiation negative regulation of cell differentiation negative regulation of osteoblast differentiation negative regulation of SMAD protein import into nucleus SMAD protein signal transduction coronary vasculature development cellular response to growth factor stimulus transforming growth factor beta receptor superfamily signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter transcription, DNA-templated transforming growth factor beta receptor signaling pathway negative regulation of SMAD protein complex assembly intracellular signal transduction positive regulation of vasoconstriction negative regulation of vasodilation negative regulation of pathway-restricted SMAD protein phosphorylation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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