Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@4e62dd2f
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:

Invitrogen

SMAD6 Polyclonal Antibody

View all (10) SMAD6 antibodies
Datasheet Created with sketchtool. Datasheet
Protocols Protocols
Questions & Answers Questions & Answers
Tech Support Created with sketchtool. Tech Support
Datasheet Created with sketchtool. Datasheet
Protocols Protocols
Questions & Answers Questions & Answers
Tech Support Created with sketchtool. Tech Support

Product Details

PA5-99401

Applications Tested Dilution Publications

Western Blot (WB)

 1:500-1:2,000 -

Immunohistochemistry (Paraffin) (IHC (P))

 1:50-1:200 -
Product Specifications

Species Reactivity

 Human, Mouse

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

A synthesized peptide derived from human SMAD6(Accession O43541), corresponding to amino acid residues G363-F389.
View antigen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Affinity chromatography

Storage buffer

 PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

 0.02% sodium azide

Storage conditions

 -20°C

RRID

AB_2818334

Target Information

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: MAD homolog 6; Mad homolog 7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; mothers against DPP homolog 6; SMAD; SMAD 6; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6

Gene Aliases: AOVD2; b2b390Clo; HsT17432; MADH6; MADH7; Msmad6; SMAD6

UniProt ID: (Human) O43541, (Mouse) O35182

Entrez Gene ID: (Human) 4091, (Mouse) 17130

Molecular Function: DNA-binding transcription factor gene-specific transcriptional regulator

Function(s)
ureteric bud development outflow tract septum morphogenesis mitral valve morphogenesis pulmonary valve morphogenesis ventricular septum development transcription, DNA-templated immune response transforming growth factor beta receptor signaling pathway zygotic specification of dorsal/ventral axis negative regulation of cell proliferation negative regulation of SMAD protein complex assembly negative regulation of ossification BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway cell-substrate adhesion response to laminar fluid shear stress aorta development negative regulation of apoptotic process response to estrogen fat cell differentiation negative regulation of pathway-restricted SMAD protein phosphorylation coronary vasculature development regulation of transcription, DNA-templated intracellular signal transduction positive regulation of vasoconstriction negative regulation of vasodilation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis
Process(es)
RNA polymerase II core promoter proximal region sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding transcription regulatory region DNA binding metal ion binding co-SMAD binding I-SMAD binding R-SMAD binding type I activin receptor binding DNA binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support
Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType: