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Proteintech
SMAD7 Polyclonal Antibody
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Product Details
25840-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SMAD7 Fusion Protein Ag13688 (1-426 aa encoded by BC074819)
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MFRTKRSAL VRRLWRSRAP GGEDEEEGAG GGGGGGELRG EGATDSRAHG AGGGGPGRAG CCLGKAVRGA KGHHHPHPPA AGAGAAGGAE ADLKALTHSV LKKLKERQLE LLLQAVESRG GTRTACLLLP GRLDCRLGPG APAGAQPAQP PSSYSLPLLL CKVFRWPDLR HSSEVKRLCC CESYGKINPE LVCCNPHHLS RLCELESPPP PYSRYPMDFL KPTADCPDAV PSSAETGGTN YLAPGGLSDS QLLLEPGDRS HWCVVAYWEE KTRVGRLYCV QEPSLDIFYD LPQGNGFCLG QLNSDNKSQL VQKVRSKIGC GIQLTREVDG VWVYNRSSYP IFIKSATLDN PDSRTLLVHK VFPGFSIKAF DYEKAYSLQR PNDHEFMQQP WTGFTVQISF VKGWGQCYTR QFISSCPCWL EVIFNSR (1-426 aa encoded by BC074819)
Target Information
SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, SMAD2, SMAD5, SMAD8 and SMAD9), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and SMAD7). SMAD1, SMAD5, SMAD8 and SMAD9 have high degrees of homology and antibodies are available that recognize sequences common to all of them. SMAD8 and SMAD9 are typically used as alternate names for one another in the literature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ16482; hSMAD7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 7; MAD homolog 8; madh8; Mothers against decapentaplegic homolog 7; Mothers against decapentaplegic homolog 8; Mothers against decapentaplegic, drosophila, homolog of, 7; mothers against DPP homolog 7; mothers against DPP homolog 8; SMAD; SMAD 7; SMAD family member 7; SMAD, mothers against DPP homolog 7
Gene Aliases: CRCS3; MADH7; MADH8; SMAD7
UniProt ID: (Human) O15105, (Mouse) O35253, (Rat) O88406
Entrez Gene ID: (Human) 4092, (Mouse) 17131, (Rat) 81516
transcription factor activity, sequence-specific DNA binding
protein binding
collagen binding
beta-catenin binding
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
transcription regulatory region DNA binding
metal ion binding
activin binding
I-SMAD binding
DNA binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
regulation of epithelial to mesenchymal transition
negative regulation of epithelial to mesenchymal transition
negative regulation of peptidyl-threonine phosphorylation
negative regulation of transcription by competitive promoter binding
regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cell-cell adhesion
negative regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of activin receptor signaling pathway
negative regulation of peptidyl-serine phosphorylation
adherens junction assembly
response to laminar fluid shear stress
cellular protein complex localization
intracellular signal transduction
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
artery morphogenesis
protein stabilization
negative regulation of ubiquitin-protein transferase activity
ventricular cardiac muscle tissue morphogenesis
regulation of cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane depolarization
pathway-restricted SMAD protein phosphorylation
negative regulation of pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
cellular response to transforming growth factor beta stimulus
regulation of transcription, DNA-templated
negative regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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