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Proteintech

SMARCA2 Polyclonal Antibody, CoraLite® Plus 488

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Product Details

CL488-26613

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:200-1:800
-

Flow Cytometry (Flow)

0.40 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SMARCA2-Specific fusion protein Ag25157

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MSTPTDPGA MPHPGPSPGP GPSPGPILGP SPGPGPSPGS VHSMMGPSPG PPSVSHPMPT MGSTDFPQEG MHQMHKPIDG IHDKGIVEDI HCGSMKGTGM RPPHPGMGPP QSPMDQHSQG YMSPHPSPLG APEHVSSPMS GGGPTPPQMP PSQPGALIPG DPQAMSQPNR GPSPFSPVQL HQLRAQILAY KMLARGQPLP ETLQLAVQGK RTLPGLQQQQ QQQQQQQQQQ QQQQQQQQQP QQQPPQPQTQ QQQQPALVNY NRPSGPGPEL SGP

Target Information

SMARCA2 encodes a protein that is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent helicase SMARCA2; BAF190B; brahma homolog; BRG1-associated factor 190B; FLJ36757; global transcription activator homologous sequence; hBRM; MGC74511; Probable global transcription activator SNF2L2; Protein brahma homolog; putative global transcription activator SNF2L2; SAMRCA2; SNF2-alpha; SNF2/SWI2-like protein 2; subunit of the SWI/SNF chromatin remodeling complex; sucrose nonfermenting 2-like protein 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; unnamed protein product

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Gene Aliases: 2610209L14Rik; BAF190; BAF190B; BIS; brahma; BRM; hBRM; hSNF2a; NCBRS; SMARCA2; SNF2; SNF2A; SNF2alpha; SNF2L2; SNF2LA; Sth1p; SWI2

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UniProt ID: (Human) P51531, (Mouse) Q6DIC0

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Entrez Gene ID: (Human) 6595, (Mouse) 67155

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Function(s)
transcription regulatory region sequence-specific DNA binding DNA binding chromatin binding transcription coactivator activity helicase activity protein binding ATP binding DNA-dependent ATPase activity hydrolase activity ATPase activity histone binding nucleosome array spacer activity nucleotide binding RNA polymerase II transcription coactivator activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides transcription regulatory region DNA binding DNA helicase
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatid development nervous system development positive regulation of cell proliferation negative regulation of cell proliferation regulation of mitotic metaphase/anaphase transition negative regulation of cell growth heterochromatin assembly positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of G0 to G1 transition positive regulation of stem cell population maintenance regulation of G1/S transition of mitotic cell cycle positive regulation of double-strand break repair regulation of nucleotide-excision repair chromatin organization nucleosome assembly transcription, DNA-templated transcription from RNA polymerase II promoter aortic smooth muscle cell differentiation
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