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SMC1 Polyclonal Antibody
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FIGURE: 1 / 1
SMC1 Antibody (BS-3568R) in Flow
Hela cells probed with Rabbit Anti-SMC1 Polyclonal Antibody (bs-3568R) at 1:10 for 30 minutes followed by incubation with Goat Anti-Rabbit IgG FITC conjugated secondary (bs-0295G-FITC) at 1:100 (green) for 40 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange).
Product Details
BS-3568R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SMC1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chromosome segregation protein SmcB; DKFZp686L19178; DXhXs423e; epididymis secretory sperm binding protein; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mitosis-specific chromosome segregation protein SMC1 homolog; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; segregation of mitotic chromosomes-like 1; SM1A; SMC; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein 1A; SMC protein 1B; SMC-1-alpha; SMC-1-beta; SMC-like 1; SMC-protein; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; SMC1alpha protein; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1 like 1; Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B; unnamed protein product
Gene Aliases: 5830426I24Rik; CDLS2; DEE85; DXS423E; EIEE85; KIAA0178; mKIAA0178; SB1.8; SMC-1A; SMC-1B; SMC1; SMC1A; SMC1alpha; SMC1B; SMC1BETA; SMC1L1; SMC1L2; SMCB
UniProt ID: (Human) Q14683, (Human) Q8NDV3, (Rat) Q9Z1M9, (Mouse) Q9CU62, (Mouse) Q920F6
Entrez Gene ID: (Human) 8243, (Human) 27127, (Rat) 63996, (Mouse) 24061, (Rat) 300121, (Mouse) 140557
sister chromatid cohesion
chromosome organization
meiotic cell cycle
DNA repair
mitotic sister chromatid cohesion
mitotic cell cycle checkpoint
meiotic nuclear division
response to radiation
stem cell population maintenance
negative regulation of DNA endoreduplication
signal transduction in response to DNA damage
cell division
cellular response to DNA damage stimulus
cell cycle
mitotic nuclear division
mitotic sister chromatid segregation
establishment of mitotic sister chromatid cohesion
establishment of meiotic sister chromatid cohesion
somatic stem cell population maintenance
response to DNA damage checkpoint signaling
mitotic spindle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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