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Invitrogen
SMC1 Polyclonal Antibody
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Product Details
PA5-116204
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A
Conjugate
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686L19178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; SM1A; SMC protein 1A; SMC protein 1B; SMC-1-alpha; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; SMC1alpha protein; Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B
Gene Aliases: CDLS2; DXS423E; KIAA0178; SB1.8; SMC1; SMC1A; SMC1alpha; SMC1B; SMC1BETA; SMC1L1; SMC1L2; SMCB
UniProt ID: (Human) Q14683, (Human) Q8NDV3
Entrez Gene ID: (Human) 8243, (Human) 27127
mitotic sister chromatid segregation
DNA repair
mitotic spindle organization
sister chromatid cohesion
mitotic sister chromatid cohesion
mitotic cell cycle checkpoint
meiotic nuclear division
response to radiation
protein sumoylation
stem cell population maintenance
negative regulation of DNA endoreduplication
signal transduction in response to DNA damage
cell division
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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