PA5-29691 targets SMC1A in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-29691 immunogen is recombinant fragment corresponding to a region within amino acids 308 and 546 of Human SMC1A.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
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Protein Aliases: CDLS2; Chromosome segregation protein SmcB; DXS423E; SB1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1; SMC1 (structural maintenance of chromosomes 1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 1; SMC1alpha; SMC1L1; SMCB; Structural maintenance of chromosomes protein 1A; yeast)-like 1
Gene Aliases: 5830426I24Rik; CDLS2; DXS423E; KIAA0178; mKIAA0178; SB1.8; SMC-1A; SMC1; SMC1A; SMC1alpha; SMC1L1; SMCB