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Proteintech
SMC1A Polyclonal Antibody
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Product Details
21695-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SMC1A Fusion Protein Ag16286 (685-1034 aa encoded by BC112127)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LKEQMKAKR KEAELRQVQS QAHGLQMRLK YSQSDLEQTK TRHLALNLQE KSKLESELAN FGPRINDIKR IIQSREREMK DLKEKMNQVE DEVFEEFCRE IGVRNIREFE EEKVKRQNEI AKKRLEFENQ KTRLGIQLDF EKNQLKEDQD KVHMWEQTVK KDENEIEKLK KEEQRHMKII DETMAQLQDL KNQHLAKKSE VNDKNHEMEE IRKKLGGANK EMTHLQKEVT AIETKLEQKR SDRHNLLQAC KMQDIKLPLS KGTMDDISQE EGSSQGEDSV SGSQRISSIY AREALIEIDY GDLCEDLKDA QAEEEIKQEM NTLQQKLNEQ QSVLQRIAAP NMKAMEKLES V (685-1034 aa encoded by BC112127)
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Chromosome segregation protein SmcB; DKFZp686L19178; epididymis secretory sperm binding protein; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mitosis-specific chromosome segregation protein SMC1 homolog; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; SM1A; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein 1A; SMC protein 1B; SMC-1-alpha; SMC-1-beta; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; SMC1alpha protein; structural maintenace of chromosomes 1B; Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B; unnamed protein product
Gene Aliases: 5830426I24Rik; CDLS2; DEE85; DXS423E; EIEE85; KIAA0178; mKIAA0178; SB1.8; SMC-1A; SMC-1B; SMC1; SMC1A; SMC1alpha; SMC1B; SMC1BETA; SMC1L1; SMC1L2; SMCB
UniProt ID: (Human) Q14683, (Human) Q8NDV3, (Mouse) Q9CU62, (Mouse) Q920F6
Entrez Gene ID: (Human) 8243, (Human) 27127, (Mouse) 24061, (Mouse) 140557
sister chromatid cohesion
chromosome organization
meiotic cell cycle
DNA repair
cellular response to DNA damage stimulus
cell cycle
mitotic sister chromatid cohesion
mitotic nuclear division
mitotic cell cycle checkpoint
meiotic nuclear division
stem cell population maintenance
negative regulation of DNA endoreduplication
signal transduction in response to DNA damage
cell division
mitotic sister chromatid segregation
response to radiation
establishment of mitotic sister chromatid cohesion
establishment of meiotic sister chromatid cohesion
somatic stem cell population maintenance
response to DNA damage checkpoint signaling
mitotic spindle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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