Immunogen sequence: LSRDIGRLKE TYEALLARFP NLRFAYKDPE KNWNRNCVKG LVASLISVKD TSATTALELV AGERLYNVVV DTEVTGKKLL ERGELKRRYT IIPLNKISAR CIAPETLRVA QNLVGPD
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 91%.
CAP-E and CAP-C (Chromosome Associated Protein-E and C) are also SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation to achieve proper segregation of genetic information during subsequent cell division. hCAP-C/hCAP-E is a component of a multiprotein complex called condensin that interacts with phosphorylation of Histone H3 resulting in the mitotic chromosome condensation. The distribution patterns of the two heterodimeric complexes in interphase nucleus indicate independent behavior of the two complexes during cell cycle. These results suggest that the two distinct complexes are involved in different aspects of mitotic chromosome organization in humar cells.
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Protein Aliases: Chromosome-associated protein E; hCAP-E; Putative uncharacterized protein DKFZp667M185; SMC protein 2; SMC2; SMC2 (structural maintenance of chromosomes 2, yeast)-like 1; SMC2 protein; SMC2 structural maintenance of chromosomes 2-like 1 (Yeast), isoform CRA_a; structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E; Structural maintenance of chromosomes 2; Structural maintenance of chromosomes protein 2; XCAP-E homolog
Gene Aliases: CAP-E; CAPE; PRO0324; SMC-2; SMC2; SMC2L1
UniProt ID: (Human) O95347
Entrez Gene ID: (Human) 10592