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SMC5 Polyclonal Antibody
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Product Details
BS-7729R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SMC5, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSMC5; MLZ-453; Protein expressed in male leptotene and zygotene spermatocytes 453; SMC protein 5; SMC-5; SMC5 structural maintenance of chromosomes 5-like 1; Structural maintenance of chromosomes protein 5; unnamed protein product
Gene Aliases: ATELS2; KIAA0594; mKIAA0594; MLZ-453; mSMC5; SMC-5; SMC5; SMC5L1
UniProt ID: (Human) Q8IY18, (Mouse) Q8CG46
Entrez Gene ID: (Human) 23137, (Mouse) 226026, (Rat) 293967
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA repair
DNA recombination
cellular response to DNA damage stimulus
cell cycle
mitotic nuclear division
positive regulation of maintenance of mitotic sister chromatid cohesion
positive regulation of mitotic metaphase/anaphase transition
cell division
cellular senescence
double-strand break repair via nonhomologous end joining
double-strand break repair
chromosome segregation
protein sumoylation
stem cell population maintenance
chromosome condensation
regulation of telomere maintenance
mitotic cell cycle phase transition
negative regulation by host of viral genome replication
chromosome organization
positive regulation of chromosome segregation
protein localization to chromosome, centromeric region
chromatin looping
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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