Immunogen sequence: PGSRLSSGGT NYSRSWNDWQ PRTDSASADP GNLKYSSSRD RGGSSSYGLQ PSNSAVVSRQ RHDDTRVHAD IQNDEKGGYS VN
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 27%.
This gene encodes a protein involved in nonsense-mediated mRNA decay as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.
Protein Aliases: 61E3.4; hSMG-1; Lambda-interacting protein; Lambda/iota protein kinase C-interacting protein; PI-3-kinase-related kinase SMG-1; Serine/threonine-protein kinase SMG1; SMG-1; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase; SMG1 phosphatidylinositol 3-kinase-related kinase
Gene Aliases: 61E3.4; ATX; KIAA0421; LIP; SMG1
UniProt ID: (Human) Q96Q15
Entrez Gene ID: (Human) 23049