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Antibody detects endogenous levels of total EST1A.
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.
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Protein Aliases: EST1 telomerase component homolog A; EST1-like protein A; Ever shorter telomeres 1A; hEST1A; hSmg5/7a; Nonsense mediated mRNA decay factor SMG6; Smg-6 homolog; Smg-6 homolog, nonsense mediated mRNA decay factor; SMG6 nonsense mediated mRNA decay factor; telomerase subunit EST1A; Telomerase-binding protein EST1A
Gene Aliases: AI317223; AU041178; C17orf31; EST1A; hSMG5/7a; KIAA0732; LRRGT00040; RGD1309609; SMG-6; SMG6
UniProt ID: (Human) Q86US8, (Mouse) P61406
Entrez Gene ID: (Human) 23293, (Mouse) 103677, (Rat) 287522
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