Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
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Protein Aliases: frizzled family member 11; HGNC:11119; Protein Gx; Protein SMOH; seven transmembrane helix receptor; SMO; Smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Gene Aliases: FZD11; Gx; SMO; SMOH
UniProt ID: (Human) Q99835
Entrez Gene ID: (Human) 6608