Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-31392
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human SMOC1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (96%), Rat (95%), Xenopus laevis (84%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Secreted modular calcium-binding protein 1 (SMOC1) is a gene located on chromosome 14q24.2, encoding a member of the SPARC (Secreted Protein, Acidic, and Rich in Cysteine) family of matricellular proteins. SMOC1 is characterized by its multiple domains that facilitate calcium binding and interaction with various components of the extracellular matrix. This protein plays a crucial role in modulating cell-matrix interactions and signaling pathways involved in cellular adhesion, migration, and differentiation. SMOC1 is expressed in multiple tissues, including the eyes, limbs, and the central nervous system, and is essential for developmental processes such as angiogenesis and tissue formation. Mutations in SMOC1 have been linked to ocular conditions like anterior segment dysgenesis and microphthalmia, reflecting its significance in eye development. Current studies focus on the protein's broader implications in developmental disorders and its potential as a therapeutic target in diseases associated with extracellular matrix dysregulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1
Gene Aliases: OAS; SMOC1
UniProt ID: (Human) Q9H4F8
Entrez Gene ID: (Human) 64093
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support