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Abnova
SMPD3 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
SMPD3 Antibody (H00055512-B01P) in WB
Western Blot analysis of SMPD3 expression in transfected 293T cell line (H00055512-T02) by SMPD3 MaxPab polyclonal antibody.
Lane 1: SMPD3 transfected lysate(72.05 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SMPD3 transfected lysate(72.05 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00055512-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SMPD3 (NP_061137.1, 1 a.a. approximately 655 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MVLYTTPFPN SCLSALHCVS WALIFPCYWL VDRLAASFIP TTYEKRQRAD DPCCLQLLCT ALFTPIYLAL LVASLPFAFL GFLFWSPLQS ARRPYIYSRL EDKGLAGGAA LLSEWKGTGP GKSFCFATAN VCLLPDSLAR VNNLFNTQAR AKEIGQRIRN GAARPQIKIY IDSPTNTSIS AASFSSLVSP QGGDGVARAV PGSIKRTASV EYKGDGGRHP GDEAANGPAS GDPVDSSSPE DACIVRIGGE EGGRPPEADD PVPGGQARNG AGGGPRGQTP NHNQQDGDSG SLGSPSASRE SLVKGRAGPD TSASGEPGAN SKLLYKASVV KKAAARRRRH PDEAFDHEVS AFFPANLDFL CLQEVFDKRA ATKLKEQLHG YFEYILYDVG VYGCQGCCSF KCLNSGLLFA SRYPIMDVAY HCYPNKCNDD ALASKGALFL KVQVGSTPQD QRIVGYIACT HLHAPQEDSA IRCGQLDLLQ DWLADFRKST SSSSAANPEE LVAFDVVCGD FNFDNCSSDD KLEQQHSLFT HYRDPCRLGP GEEKPWAIGT LLDTNGLYDE DVCTPDNLQK VLESEEGRRE YLAFPTSKSS GQKGRKELLK GNGRRIDYML HAEEGLCPDW KAEVEEFSFI TQLSGLTDHL PVAMRLMVSS GEEEA
Target Information
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSMase-2; SMPD3; Sphingomyelin phosphodiesterase 3; unnamed protein product
Gene Aliases: NSMASE2; SMPD3
UniProt ID: (Human) Q9NY59
Entrez Gene ID: (Human) 55512
skeletal system development
ossification
endochondral ossification
chondrocyte development
hematopoietic progenitor cell differentiation
regulation of leukocyte migration
chondrocyte development involved in endochondral bone morphogenesis
lipid metabolic process
sphingolipid metabolic process
ceramide metabolic process
sphingomyelin metabolic process
sphingomyelin catabolic process
signal transduction
polysaccharide transport
peptide hormone secretion
bone mineralization
lung development
BMP signaling pathway
collagen metabolic process
cellular response to reactive oxygen species
multicellular organism growth
positive regulation of mitotic nuclear division
platelet-derived growth factor receptor signaling pathway
lung alveolus development
positive regulation of smooth muscle cell proliferation
cartilage development
negative regulation of protein kinase B signaling
bone development
respiratory system development
regulation of cartilage development
cellular response to hydrogen peroxide
G1 to G0 transition
cellular response to magnesium ion
cellular response to tumor necrosis factor
cellular response to redox state
DNA biosynthetic process
extracellular matrix assembly
sphingolipid mediated signaling pathway
dentinogenesis
bone growth
mitotic nuclear division
cellular response to oxidised low-density lipoprotein particle stimulus
regulation of hyaluronan biosynthetic process
negative regulation of hyaluronan biosynthetic process
cellular response to peptide
positive regulation of exosomal secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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