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Product Details
PA5-61204
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SMPD4. Recombinant protein control fragment (Product #RP-98451).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647660
Product Specific Information
Immunogen sequence: ASLKADSINK PFAQQCQDLV KVIEDFPAKE LHTIFPWLVE SIFGSLDGVL VGWNLRCLQG RVNPVEYSIV MEFLDPGGPM MKLVYKLQAE DYKFDFPVSY^M
^M
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 94%.
Target Information
The protein encoded by SMPD4 is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neutral sphingomyelinase 3; Neutral sphingomyelinase III; neutral sphingomyelinase-3; nSMase-3; SKNY protein; Sphingomyelin phosphodiesterase 4; sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Gene Aliases: KIAA1418; NET13; NSMASE-3; NSMASE3; SKNY; SMPD4
UniProt ID: (Human) Q9NXE4
Entrez Gene ID: (Human) 55627
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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