Immunogen sequence: ASLKADSINK PFAQQCQDLV KVIEDFPAKE LHTIFPWLVE SIFGSLDGVL VGWNLRCLQG RVNPVEYSIV MEFLDPGGPM MKLVYKLQAE DYKFDFPVSY
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 94%.
The protein encoded by SMPD4 is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Neutral sphingomyelinase 3; Neutral sphingomyelinase III; neutral sphingomyelinase-3; nSMase-3; SKNY protein; Sphingomyelin phosphodiesterase 4; sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Gene Aliases: KIAA1418; NET13; NSMASE-3; NSMASE3; SKNY; SMPD4
UniProt ID: (Human) Q9NXE4
Entrez Gene ID: (Human) 55627