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SMPD4 Antibody (PA5-78573) in IHC (P)
SMPD4 Polyclonal Antibody detects SMPD4 protein at cytosol on mouse ovary by immunohistochemical analysis. Sample: Paraffin-embedded mouse ovary. SMPD4 Polyclonal Antibody (Product # PA5-78573) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-78573
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human SMPD4. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.78 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 0.1M glycine, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2736636
Product Specific Information
Predicted Reactivity: Human (100%), Bovine (88%)^M
^M
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by SMPD4 is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neutral membrane (neutral sphingomyelinase-3); Neutral sphingomyelinase 3; Neutral sphingomyelinase III; neutral sphingomyelinase-3; nSMase-3; nSMase3; SKNY protein; Sphingomyelin phosphodiesterase 4; sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Gene Aliases: 4122402O22Rik; KIAA1418; mKIAA1418; NET13; NSMASE-3; NSMASE3; RGD1310674; SKNY; SMPD4
UniProt ID: (Human) Q9NXE4, (Mouse) Q6ZPR5
Entrez Gene ID: (Human) 55627, (Mouse) 77626, (Rat) 303790
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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