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Product Details
23567-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SMTN Fusion Protein Ag19983 (458-811 aa encoded by BC034237)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KTTFTIEIK DGRGQASTGR VLLPTGNQRA ELTLGLRAPP TLLSTSSGGK STITRVNSPG TLARLGSVTH VTSFSHAPPS SRGGCSIKME PEPAEPLAAA VEAANGAEQT RVNKAPEGRS PLSAEELMTI EDEGVLDKML DQSTDFEERK LIRAALRELR QRKRDQRDKE RERRLQEARG RPGEGRGNTA TETTTRHSQR AADGSAVSTV TKTERLVHSN DGTRTARTTT VESSFVRRSE NGSGSTMMQT KTFSSSSSSK KMGSIFDRED QASPRAGSLA ALEKRQAEKK KELMKAQSLP KTSASQARKA MIEKLEKEGA AGSPGGPRAA VQRSTSFGVP NANSIKQMLL DWCRA (458-811 aa encoded by BC034237)
Target Information
Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed to smoothelin are a useful tool to monitor SMC differentiation. Smoothelin is exclusively expressed in fully differentiated (contractile) SMCs. RNA and protein analyses reveal a broad species distribution of this protein. Cells with SMC-like characteristics, such as myofibroblasts, myoepithelial cells, and skeletal and cardiac muscle do not contain smoothelin. Confocal scanning laser microscopy of tissue sections, as well as transfection studies, show a filamentous organization of smoothelin that is different from that of desmin and vimentin. Smoothelin colocalizes with actin stress fibers. Two tissue specific isoforms have been identified: a 59 kDa isoform specific for visceral SMC; and a 100 kDa specific for vascular SMC. Human smoothelin is encoded by a single copy gene which is located on chromosome 22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ35365; FLJ38597; Smoothelin
Gene Aliases: SMSMO; SMTN
UniProt ID: (Human) P53814, (Mouse) Q921U8
Entrez Gene ID: (Human) 6525, (Mouse) 29856
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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