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Proteintech

SNAI1 Polyclonal Antibody

67 References
View all (23) SNAIL antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
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Product Details

Tested Applications
Dilution
ChIP assay (ChIP)
Assay-dependent
Immunofluorescence (IF)
Assay-dependent
Immunohistochemistry (IHC)
Assay-dependent
Immunoprecipitation (IP)
0.5-4.0 µg
Western Blot (WB)
1:500-1:1000
Published Applications
Western Blot (WB)
See 51 publications below
Immunohistochemistry (IHC)
See 7 publications below
Immunofluorescence (IF)
See 5 publications below
ChIP assay (ChIP)
See 1 publication below
Miscellaneous PubMed (MISC)
See 3 publications below
Product Specifications
Species Reactivity
Human, Mouse, Rat
Published species
Human, Mouse, Rat
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
SNAI1 Fusion Protein Ag3723
Conjugate
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C

Target Information

Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Protein sna; Protein snail homolog 1; SLUGH2; SNA; SNAH; SNAI1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail homolog 1; snail homolog 1 (Drosophila); SNAIL1; Zinc finger protein SNAI1

Gene Aliases: AI194338; dJ710H13.1; SLUGH2; SNA; Sna1; SNAH; SNAI1; SNAIL; SNAIL1

UniProt ID: (Human) O95863, (Mouse) Q02085

Entrez Gene ID: (Human) 6615, (Mouse) 20613, (Rat) 116490

Function(s)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation mesoderm formation epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition negative regulation of vitamin D biosynthetic process cell migration positive regulation of cell migration hair follicle morphogenesis negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription, DNA-templated palate development cartilage morphogenesis trophoblast giant cell differentiation negative regulation of cell differentiation involved in embryonic placenta development left/right pattern formation Notch signaling involved in heart development negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of bicellular tight junction assembly regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development mesoderm development negative regulation of transcription, DNA-templated negative regulation of cell cycle
Process(es)
RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding kinase binding metal ion binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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