|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human SNAIL|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128.
PA5-11923 was used in immunocytochemistry and western blot to assess the promotion of wnt3a stabilization through suppression of miR-128 by AurkA that controls self-renewal of breast cancer-initiating cells
|Eterno V,Zambelli A,Villani L,Tuscano A,Manera S,Spitaleri A,Pavesi L,Amato A||Scientific reports (6:null)||2016|
A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an epithelial-mesenchymal transition-independent manner.
PA5-11923 was used in immunohistochemistry (paraffin) to identify and characterize vessels that encapsulated tumor clusters in hepatocellular carcinoma sections.
|Fang JH,Zhou HC,Zhang C,Shang LR,Zhang L,Xu J,Zheng L,Yuan Y,Guo RP,Jia WH,Yun JP,Chen MS,Zhang Y,Zhuang SM||Hepatology (Baltimore, Md.) (62:452)||2015|