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Proteintech
SNAP23 Polyclonal Antibody
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Product Details
10825-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Goat,
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SNAP23 Fusion Protein Ag1269 (1-211 aa encoded by BC000148)
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDNLSSEEI QQRAHQITDE SLESTRRILG LAIESQDAGI KTITMLDEQK EQLNRIEEGL DQINKDMRET EKTLTELNKC CGLCVCPCNR TKNFESGKAY KTTWGDGGEN SPCNVVSKQP GPVTNGQLQQ PTTGAASGGY IKRITNDARE DEMEENLTQV GSILGNLKDM ALNIGNEIDA QNPQIKRITD KADTNRDRID IANARAKKLI DS (1-211 aa encoded by BC000148)
Target Information
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: OTTHUMP00000161263; SNAP-23; Synaptosomal-associated protein 23; synaptosomal-associated protein 23 kD; synaptosomal-associated protein, 23 kD; synaptosomal-associated protein, 23kD; synaptosomal-associated protein, 23kDa; synaptosome associated protein 23kDa; Syndet; Vesicle-membrane fusion protein SNAP-23
Gene Aliases: 23kDa; AA408749; HsT17016; SNAP-23; SNAP23; SNAP23A; SNAP23B; Sndt; Syndet
UniProt ID: (Human) O00161, (Mouse) O09044, (Rat) O70377
Entrez Gene ID: (Human) 8773, (Mouse) 20619, (Rat) 64630
histamine secretion by mast cell
post-Golgi vesicle-mediated transport
vesicle targeting
protein transport
synaptic vesicle priming
synaptic vesicle fusion to presynaptic active zone membrane
membrane fusion
protein complex assembly
transport
exocytosis
vesicle-mediated transport
regulation of exocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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