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Abnova
SNCAIP Polyclonal Antibody, MaxPab™
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Product Details
H00009627-B01P
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SNCAIP (AAH94759.1, 1 a.a. approximately 603 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTYLIQSHHS RRSQNCAEDV IRKTKTDQNG QLECVRWMVS ETEAIAELSC SKDFPSLIHY AGCYGQEKIL LWLLQFMQEQ GISLDEVDQD GNSAVHVASQ HGYLGCIQTL VEYGANVTMQ NHAGEKPSQS AERQGHTLCS RYLVVVETCM SLASQVVKLT KQLKEQTVER VTLQNQLQQF LEAQKSEGKS LPSSPSSPSS PASRKSQWKS PDADDDSVAK SKPGVQEGIQ VLGSLSASSR ARPKAKDEDS DKILRQLLGK EISENVCTQE KLSLEFQDAQ ASSRNSKKIP LEKRELKLAR LRQLMQRSLS ESDTDSNNSE DPKTTPVRKA DRPRPQPIVE SVESMGSAES LHLMIKKHTL ASGGRRFPFS IKASKSLDGH SPSPTSESSE PDLESQYPGS GSIPPNQPSG DPQQPSPDST AAQKVATSPK SALKSPSSKR RTSQNLKLRV TFEEPVVQME QPSLELNGEK DKDKGRTLQR TSTSNESGDQ LKRPFGAFRS IMETLSGNQN NNNNYQAANQ LKTSTLPLTS LGRKTDAKGN PASSASKGKN KAEMYSSCIN LSSNMLIEEH LCNDTRHNDI NRKMKKSYSI KHIAEPESKE LFL
Target Information
Parkinson is the second most common neurodegenerative disease after Alzheimer's. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-synuclein-interacting protein; MGC39814; Sph1; Synphilin 1; Synphilin-1; synuclein, alpha interacting protein (synphilin); unnamed protein product
Gene Aliases: SNCAIP; Sph1; SYPH1
UniProt ID: (Human) Q9Y6H5
Entrez Gene ID: (Human) 9627, (Rat) 307309
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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