This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-27474 targets U1A in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-27474 immunogen is recombinant fragment corresponding to a region within amino acids 139 and 282 of Human U1A.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation.
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Protein Aliases: Mud1; protein A of the U1 small nuclear RNA; U1 small nuclear ribonucleoprotein A; U1 small nuclear RNP-specific A; U1 snRNP A; U1 snRNP-specific protein A; U1-A; U1A
Gene Aliases: C430021M15Rik; Mud1; Rnu1a-1; Rnu1a1; SNRPA; U1-A; U1A