This is a rabbit polyclonal antibody raised against the full length SNRPA1 of human origin.
Immunogen sequence: MVKLTAELI EQAAQYTNAV RDRELDLRGY KIPVIENLGA TLDQFDAIDF SDNEIRKLDG FPLLRRLKTL LVNNNRICRI GEGLDQALPC LTELILTNNS LVELGDLDPL ASLKSLTYLS ILRNPVTNKK HYRLYVIYKV PQVRVLDFQK VKLKERQEAE KMFKGKRGAQ LAKDIARRSK TFNPGAGLPT DKKKGGPSPG DVEAIKNAIA NASTLAEVER LKGLLQSGQI PGRERRSGPT DDGEEEMEED TVTNGS (1-255 aa encoded by B C022816)
SNRPA1 (U2 snRNP-A) is located in gene map locus 15q26. 3 and is a 28 kDa protein, isa specific component of U2 snRNP particle and consists of a unique N-terminal leucine-rich region and an extremely hydrophobic RNA-binding C-terminal region. It lacks segments homologous to RNP1 and RNP2, commonA. A motifs found in several RNA-binding proteins. It associates with U2 snRNP and participates in transcription and pre-mRNA splicing. It might play an important role in cell division and proliferation. Patients with connective tissue disorders often produce autoantibodies against snRNP particles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: U2 small nuclear ribonucleoprotein A'; U2 small nuclear ribonucleoprotein polypeptide A'; U2 snRNP A'
Gene Aliases: Lea1; SNRPA1
UniProt ID: (Human) P09661
Entrez Gene ID: (Human) 6627
Molecular Function: RNA splicing factor