FIGURE: 1 / 7
Immunogen sequence: FNSGAKQRV IRMVEMQKDP MEPPRFKINK KIPRGPPSPP APVMHSPSRK MTVKEQQEWK IPPCISNWKN AKGYTIPLDK RLAADGRGLQ TVHINENFAK LAEALYIADR KAREAVEMRA QVERKMAQKE KEKHEEKLRE MAQKARERRA GIKTHVEKED GEARERDEIR HDRRKERQHD RNLSRAAPDK RSKLQRNENR DISEVIALGV PNPRTSNEVQ YDQRLFNQSK GMDSGFAGGE DEIYNVYDQA WRGGKDMAQS IYRPSKNLDK DMYGDDLEAR IKTNRFVPDK EFSGSDRRQR GREGPVQFEE DPFGLDKFLE EAKQHGGSKR PSDSSRPKEH EHEGKKRRKE (188-536 aa encoded by BC108903)
CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.
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Protein Aliases: homolog of Drosophila BX42; Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; PPS; SKI interacting protein; SKI-interacting protein; SNW domain-containing protein 1
Gene Aliases: Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP; SNW1
UniProt ID: (Human) Q13573
Entrez Gene ID: (Human) 22938