Proteintech

SNX1 Polyclonal Antibody

View all (14) SNX1 antibodies

Questions & Answers

Questions & Answers

Product Image Gallery

SNX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 10304-1-AP ( SNX1 Antibody) at dilution of 1:200 (under 40x lens).

SNX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 10304-1-AP (SNX1 Antibody) at dilution of 1:200 (under 40x lens).

SNX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 10304-1-AP (SNX1 Antibody) at dilution of 1:200 (under 10x lens).

SNX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human pancreas cancer using 10304-1-AP (SNX1 antibody) at dilution of 1:100 (under 25x lens).

SNX1 Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 10304-1-AP (SNX1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

SNX1 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 10304-1-AP (SNX1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

SNX1 Antibody in Immunoprecipitation (IP) — IP result of anti-SNX1 (IP:10304-1-AP, 4ug; Detection:10304-1-AP 1:800) with HeLa cells lysate 2000ug.

Product Details

10304-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 3 publications 3 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	-	View 3 publications 3 publications
Immunoprecipitation (IP)	0.5-4.0 µg	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	SNX1 Fusion Protein Ag0499 (81-287 aa encoded by BC000357) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.2 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: QDQEPQDLF ADATVELSLD STQNNQKKVL AKTLISLPPQ EATNSSKPQP TYEELEEEEQ EDQFDLTVGI TDPEKIGDGM NAYVAYKVTT QTSLPLFRSK QFAVKRRFSD FLGLYEKLSE KHSQNGFIVP PPPEKSLIGM TKVKVGKEDS SSAEFLEKRR AALERYLQRI VNHPTMLQDP DVREFLEKEE LPRAVGTQTL SGAGLLKM (81-287 aa encoded by BC000357 )

Target Information

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sharma R,Gulia R,Bhattacharyya S

Wed Oct 03 00:00:00 EDT 2018

A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sharma R,Gulia R,Bhattacharyya S

Wed Oct 03 00:00:00 EDT 2018

Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells.

PloS one

Yamasaki T,Suzuki A,Hasebe R,Horiuchi M

Mon Apr 27 00:00:00 EDT 2015

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.

The Journal of biological chemistry

Villar VA,Jones JE,Armando I,Asico LD,Escano CS,Lee H,Wang X,Yang Y,Pascua-Crusan AM,Palmes-Saloma CP,Felder RA,Jose PA

Fri Jan 04 00:00:00 EST 2013

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Molecular biology of the cell

Gomez TS,Gorman JA,de Narvajas AA,Koenig AO,Billadeau DD

Wed Aug 01 00:00:00 EDT 2012

Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells.

BMC neuroscience

Jin J,Davis J,Zhu D,Kashima DT,Leroueil M,Pan C,Montine KS,Zhang J

Thu Aug 16 00:00:00 EDT 2007

Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells.

BMC neuroscience

Jin J,Davis J,Zhu D,Kashima DT,Leroueil M,Pan C,Montine KS,Zhang J

Thu Aug 16 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: MGC8664; SNX1A; sorting nexin 1A; Sorting nexin-1

Gene Aliases: HsT17379; SNX1; VPS5

UniProt ID: (Human) Q13596, (Mouse) Q9WV80, (Rat) Q99N27

Entrez Gene ID: (Human) 6642, (Mouse) 56440, (Rat) 84471

Molecular Function: scaffold/adaptor protein

intracellular protein transport vesicle organization receptor internalization early endosome to Golgi transport retrograde transport, endosome to Golgi positive regulation of protein catabolic process lamellipodium morphogenesis cell-cell adhesion transport endocytosis protein transport endosomal transport

Process(es)

epidermal growth factor receptor binding insulin receptor binding protein binding phosphatidylinositol binding identical protein binding protein homodimerization activity protein heterodimerization activity cadherin binding involved in cell-cell adhesion transferrin receptor binding leptin receptor binding lipid binding