Proteintech

SNX1 Polyclonal Antibody

SNX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SNX1 Antibody (10304-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 10304-1-AP) (SNX1 Antibody) at dilution of 1:200 (under 10x lens).

SNX1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10304-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SNX1 Fusion Protein Ag0499 (81-287 aa encoded by BC000357)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QDQEPQDLF ADATVELSLD STQNNQKKVL AKTLISLPPQ EATNSSKPQP TYEELEEEEQ EDQFDLTVGI TDPEKIGDGM NAYVAYKVTT QTSLPLFRSK QFAVKRRFSD FLGLYEKLSE KHSQNGFIVP PPPEKSLIGM TKVKVGKEDS SSAEFLEKRR AALERYLQRI VNHPTMLQDP DVREFLEKEE LPRAVGTQTL SGAGLLKM (81-287 aa encoded by BC000357 )

Target Information

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Sde Phosphoribosyl-Linked Ubiquitin Transferases protect the Legionella pneumophila vacuole from degradation by the host.

bioRxiv : the preprint server for biology

Kim S,Isberg RR

Mon Mar 20 00:00:00 UTC 2023

Diabetes is accompanied by changes in the levels of proteins involved in endosomal GLUT4 trafficking in obese human skeletal muscle.

Endocrinology, diabetes & metabolism

Livingstone R,Bryant NJ,Boyle JG,Petrie JR,Gould GW

Thu Sep 01 00:00:00 UTC 2022

Retromer dysfunction in amyotrophic lateral sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Pérez-Torres EJ,Utkina-Sosunova I,Mishra V,Barbuti P,De Planell-Saguer M,Dermentzaki G,Geiger H,Basile AO,Robine N,Fagegaltier D,Politi KA,Rinchetti P,Jackson-Lewis V,Harms M,Phatnani H,Lotti F,Przedborski S

Tue Jun 28 00:00:00 UTC 2022

Increased AT₁ receptor expression mediates vasoconstriction leading to hypertension in Snx1^-/- mice.

Hypertension research : official journal of the Japanese Society of Hypertension

Liu C,Li X,Fu J,Chen K,Liao Q,Wang J,Chen C,Luo H,Jose PA,Yang Y,Yang J,Zeng C

Sun Aug 01 00:00:00 UTC 2021

Sorting nexin 1 loss results in increased oxidative stress and hypertension.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yang J,Asico LD,Beitelshees AL,Feranil JB,Wang X,Jones JE,Armando I,Cuevas SG,Schwartz GL,Gums JG,Chapman AB,Turner ST,Boerwinkle E,Cooper-DeHoff RM,Johnson JA,Felder RA,Weinman EJ,Zeng C,Jose PA,Villar VAM

Mon Jun 01 00:00:00 UTC 2020

A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sharma R,Gulia R,Bhattacharyya S

Wed Oct 03 00:00:00 UTC 2018

A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sharma R,Gulia R,Bhattacharyya S

Wed Oct 03 00:00:00 UTC 2018

A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sharma R,Gulia R,Bhattacharyya S

Wed Oct 03 00:00:00 UTC 2018

A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sharma R,Gulia R,Bhattacharyya S

Wed Oct 03 00:00:00 UTC 2018

Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells.

PloS one

Yamasaki T,Suzuki A,Hasebe R,Horiuchi M

Mon Apr 27 00:00:00 UTC 2015

PloS one

Yamasaki T,Suzuki A,Hasebe R,Horiuchi M

Mon Apr 27 00:00:00 UTC 2015

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.

The Journal of biological chemistry

Villar VA,Jones JE,Armando I,Asico LD,Escano CS,Lee H,Wang X,Yang Y,Pascua-Crusan AM,Palmes-Saloma CP,Felder RA,Jose PA

Fri Jan 04 00:00:00 UTC 2013

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.

The Journal of biological chemistry

Villar VA,Jones JE,Armando I,Asico LD,Escano CS,Lee H,Wang X,Yang Y,Pascua-Crusan AM,Palmes-Saloma CP,Felder RA,Jose PA

Fri Jan 04 00:00:00 UTC 2013

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Molecular biology of the cell

Gomez TS,Gorman JA,de Narvajas AA,Koenig AO,Billadeau DD

Wed Aug 01 00:00:00 UTC 2012

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Molecular biology of the cell

Gomez TS,Gorman JA,de Narvajas AA,Koenig AO,Billadeau DD

Wed Aug 01 00:00:00 UTC 2012

Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells.

BMC neuroscience

Jin J,Davis J,Zhu D,Kashima DT,Leroueil M,Pan C,Montine KS,Zhang J

Thu Aug 16 00:00:00 UTC 2007

Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells.

BMC neuroscience

Jin J,Davis J,Zhu D,Kashima DT,Leroueil M,Pan C,Montine KS,Zhang J

Thu Aug 16 00:00:00 UTC 2007

Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells.

BMC neuroscience

Jin J,Davis J,Zhu D,Kashima DT,Leroueil M,Pan C,Montine KS,Zhang J

Thu Aug 16 00:00:00 UTC 2007

Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells.

BMC neuroscience

Jin J,Davis J,Zhu D,Kashima DT,Leroueil M,Pan C,Montine KS,Zhang J

Thu Aug 16 00:00:00 UTC 2007

Bioinformatics

Protein Aliases: MGC8664; SNX1A; sorting nexin 1A; Sorting nexin-1

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Gene Aliases: HsT17379; SNX1; VPS5

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UniProt ID: (Human) Q13596, (Mouse) Q9WV80, (Rat) Q99N27

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Entrez Gene ID: (Human) 6642, (Mouse) 56440, (Rat) 84471

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Function(s)

epidermal growth factor receptor binding insulin receptor binding protein binding phosphatidylinositol binding identical protein binding protein homodimerization activity protein heterodimerization activity cadherin binding involved in cell-cell adhesion transferrin receptor binding leptin receptor binding lipid binding scaffold/adaptor protein

Process(es)

intracellular protein transport vesicle organization receptor internalization early endosome to Golgi transport retrograde transport, endosome to Golgi positive regulation of protein catabolic process lamellipodium morphogenesis cell-cell adhesion transport endocytosis protein transport endosomal transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNX1 Polyclonal Antibody

SNX1 Antibody (10304-1-AP) in IHC (P)

Product Details

10304-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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