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The target sequence has 94% sequence homology with rat and bovine.
SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
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Protein Aliases: methamphetamine-responsive transcript 1; RP11-98D18.12-005; Sorting nexin-27
Gene Aliases: 5730552M22Rik; ESTM45; ESTM47; KIAA0488; MRT1; MY014; R75405; SNX27
UniProt ID: (Human) Q96L92, (Mouse) Q3UHD6
Entrez Gene ID: (Human) 81609, (Mouse) 76742
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