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OriGene
SOCS1 Polyclonal Antibody
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FIGURE: 1 / 2
SOCS1 Antibody (TA890038) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS1(RC220847, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS1 r. Positive lysates LY401230 (100 µg) and LC401230 (20 µg) can be purchased separately from OriGene.
Product Details
TA890038
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human SOCS1
Conjugate
Form
Liquid
Concentration
0.97 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; JAK2-binding protein; SOCS-1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP-3
Gene Aliases: CIS1; CISH1; Cish7; JAB; SOCS-1; SOCS1; SSI-1; SSI1; TIP3
UniProt ID: (Human) O15524, (Mouse) O35716
Entrez Gene ID: (Human) 8651, (Mouse) 12703, (Rat) 252971
regulation of protein phosphorylation
negative regulation of protein kinase activity
JAK-STAT cascade
regulation of activation of JAK2 kinase activity
protein ubiquitination
cytokine-mediated signaling pathway
organ regeneration
response to estradiol
response to lipopolysaccharide
response to progesterone
regulation of growth
response to drug
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat3 protein
response to peptide hormone
fat cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
regulation of cytokine secretion
regulation of interferon-gamma-mediated signaling pathway
cellular response to amino acid stimulus
negative regulation of signal transduction
intracellular signal transduction
regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of catalytic activity
regulation of JAK-STAT cascade
response to cytokine
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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