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Proteintech
SOCS2 Polyclonal Antibody
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Product Details
26206-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SOCS2 fusion protein Ag24394
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Amount
67.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SAGPTNLRIE YQDGKFRLDS IICVKSKLKQ FDSVVHLIDY YVQMCKDKRT GPEAPRNGTV HLYLTKPLYT SAPSLQHLCR LTINKCTGAI WGLPLPTRLK DYLEEYKFQV
Target Information
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CIS-2; cytokine inducible SH2-containing protein 2; Cytokine-inducible SH2 protein 2; SOCS-2; SSI-2; STAT-induced STAT inhibitor 2; Suppressor of cytokine signaling 2; unnamed protein product
Gene Aliases: CIS2; Cish2; SOCS-2; SOCS2; SSI-2; SSI2; STATI2
UniProt ID: (Human) O14508, (Rat) O88582
Entrez Gene ID: (Human) 8835, (Rat) 84607
cytokine receptor binding
growth hormone receptor binding
insulin-like growth factor receptor binding
protein binding
JAK pathway signal transduction adaptor activity
phosphorylation-dependent protein binding
protein binding, bridging involved in substrate recognition for ubiquitination
molecular_function
protein kinase inhibitor activity
kinase modulator
regulation of cell growth
JAK-STAT cascade
lactation
regulation of signal transduction
negative regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
response to estradiol
cellular response to hormone stimulus
intracellular signal transduction
erythropoietin-mediated signaling pathway
regulation of multicellular organism growth
negative regulation of multicellular organism growth
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of neuron differentiation
negative regulation of JAK-STAT cascade
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
mammary gland alveolus development
negative regulation of protein kinase activity
aging
response to peptide hormone
negative regulation of insulin receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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