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Proteintech
SOCS3 Polyclonal Antibody
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Product Details
14025-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SOCS3 Fusion Protein Ag5170 (1-225 aa encoded by BC060858)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVTHSKFPA AGMSRPLDTS LRLKTFSSKS EYQLVVNAVR KLQESGFYWS AVTGGEANLL LSAEPAGTFL IRDSSDQRHF FTLSVKTQSG TKNLRIQCEG GSFSLQSDPR STQPVPRFDC VLKLVHHYMP PPGAPSFPSP PTEPSSEVPE QPSAQPLPGS PPRRAYYIYS GGEKIPLVLS RPLSSNVATL QHLCRKTVNG HLDSYEKVTQ LPGPIREFLD QYDAPL (1-225 aa encoded by B C060858)
Target Information
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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