PA1-29534 detects SOCS3 from rat, mouse, human samples.
PA1-29534 has been successfully used in ELISA, immunoprecipitation, Western blot applications.
The PA1-29534 immunogen is: Synthetic peptide (QLPGPIREFLDQYDAPL)corresponding to amino acids 209-225 of thehuman / rat / mouse SOCS 3.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATOD4; CIS-3; CIS3; Cish3; cytokine inducible SH2-containing protein 3; Cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; MGC71791; Protein EF-10; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3
Gene Aliases: ATOD4; CIS3; Cish3; EF-10; Ef10; SOCS-3; SOCS3; SSI-3; SSI3