PA5-28098 targets SOCS3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28098 immunogen is synthetic peptide corresponding to a region within amino acids 163 and 225 of Human SOCS3.
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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
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Protein Aliases: ATOD4; CIS-3; CIS3; Cish3; cytokine-induced SH2 protein 3; Cytokine-inducible SH2 protein 3; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3
Gene Aliases: ATOD4; CIS3; Cish3; SOCS-3; SOCS3; SSI-3; SSI3
UniProt ID: (Human) O14543
Entrez Gene ID: (Human) 9021