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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 225 of Human SOCS3|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29628 targets SOCS3 in WB applications and shows reactivity with Human samples.
The PA5-29628 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 225 of Human SOCS3.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ATOD4; CIS-3; CIS3; Cish3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; SSI-3; SSI3; STAT-induced STAT inhibitor 3
ATOD4; CIS3; Cish3; SOCS-3; SOCS3; SSI-3; SSI3