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Invitrogen
SOCS5 Polyclonal Antibody
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Product Details
PA5-142022
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence DKVGKMWNNFK-C (aa 2-12).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIS-6; Cytokine-inducible SH2 protein 6; Cytokine-inducible SH2-containing protein 5; SOCS-5; Suppressor of cytokine signaling 5; unnamed protein product
Gene Aliases: CIS6; CISH5; CISH6; KIAA0671; SOCS-5; SOCS5
UniProt ID: (Human) O75159
Entrez Gene ID: (Human) 9655
epidermal growth factor receptor signaling pathway
negative regulation of epidermal growth factor-activated receptor activity
JAK-STAT cascade
negative regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-6 production
intracellular signal transduction
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
negative regulation of inflammatory response
cellular response to low-density lipoprotein particle stimulus
negative regulation of monocyte chemotactic protein-1 production
vascular endothelial cell response to fluid shear stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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