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Invitrogen
SOCS6 Polyclonal Antibody
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Product Details
PA5-50263
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein corresponding to a region derived from internal residues of human suppressor of cytokine signaling 6
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total SOCS-6 protein.
Target Information
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CIS-4; cytokine inducible SH2-containing protein 4; cytokine inducible SH2-containing protein CIS4; Cytokine-inducible SH2 protein 4; SH2 domain containing SOCS box protein SOCS6; SOCS-4; SOCS-6; STAT induced STAT inhibitor-4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6
Gene Aliases: 1500012M23Rik; 5830401B18Rik; AI447482; CIS-4; CIS4; Cish4; HSPC060; SOCS-4; SOCS-6; SOCS4; SOCS6; SSI4; STAI4; STATI4
UniProt ID: (Human) O14544, (Mouse) Q9JLY0
Entrez Gene ID: (Human) 9306, (Mouse) 54607
defense response
JAK-STAT cascade
negative regulation of signal transduction
proteasomal protein catabolic process
protein ubiquitination
intracellular signal transduction
regulation of growth
negative regulation of T cell activation
cellular glucose homeostasis
negative regulation of protein kinase activity
cytokine-mediated signaling pathway
negative regulation of JAK-STAT cascade
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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