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Invitrogen

SOD2 Polyclonal Antibody

View all (44) SOD2 (MnSOD) antibodies

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SOD2 Polyclonal Antibody

Product Details

PA5-81037

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-

ELISA (ELISA)

1:5,000-1:10,000
-

Immunoprecipitation (IP)

1-4 µL/mg of lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human SOD2 protein (Lys25-Lys222)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2788289

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

This antibody has specificity for Human SOD2.

Target Information

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; gastric cancer-associated lncRNA 1; indophenoloxidase B; IPO B; manganese-containing superoxide dismutase; mangano-superoxide dismutase; Mn superoxide dismutase; Mn-superoxide dismutase; superoxide dismutase; superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial; unnamed protein product

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Gene Aliases: GC1; GClnc1; IPO-B; IPOB; lncRNA-GC1; Mn-SOD; MNSOD; MVCD6; SOD2

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UniProt ID: (Human) P04179

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Entrez Gene ID: (Human) 6648

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Function(s)
DNA binding superoxide dismutase activity protein binding oxidoreductase activity oxygen binding enzyme binding manganese ion binding identical protein binding metal ion binding
Process(es)
response to reactive oxygen species response to superoxide response to hypoxia release of cytochrome c from mitochondria liver development detection of oxygen vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure regulation of transcription from RNA polymerase II promoter glutathione metabolic process superoxide metabolic process response to oxidative stress mitochondrion organization heart development locomotory behavior regulation of blood pressure negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes response to xenobiotic stimulus post-embryonic development response to manganese ion response to zinc ion response to selenium ion response to gamma radiation positive regulation of hydrogen peroxide biosynthetic process response to activity removal of superoxide radicals respiratory electron transport chain hemopoiesis positive regulation of cell migration response to nutrient levels oxygen homeostasis response to lipopolysaccharide response to L-ascorbic acid response to silicon dioxide cellular response to oxidative stress response to isolation stress response to immobilization stress vasodilation response to hydrogen peroxide superoxide anion generation hydrogen peroxide metabolic process negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation response to cadmium ion negative regulation of fibroblast proliferation neuron development response to axon injury erythrophore differentiation hydrogen peroxide biosynthetic process protein homotetramerization response to electrical stimulus regulation of mitochondrial membrane potential response to hyperoxia multicellular organismal iron ion homeostasis response to magnetism cellular response to ethanol negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of membrane hyperpolarization negative regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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