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Invitrogen
SORL1 Polyclonal Antibody
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FIGURE: 1 / 1
SORL1 Antibody (PA5-88941) in WB
Western blot analysis of SORL1 in extracts of SH-SY5Y cells. Samples were incubated with SORL1 Polyclonal antibody (Product # PA5-88941) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-88941
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 2065-2214 of human SORL1 (NP_0030961)
Conjugate
Form
Liquid
Concentration
0.93 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DSAMNITAYL GNTTDNFFKI SNLKMGHNYT FTVQARCLFG NQICGEPAIL LYDELGSGAD ASATQAARST DVAAVVVPIL FLILLSLGVG FAILYTKHRR LQSSFTAFAN SHYSSRLGSA IFSSGDDLGE DDEDAPMITG FSDDVPMVIA; Positive Samples: SH-SY5Y, HepG2; Cellular Location: Endosome, Golgi apparatus, Membrane, Single-pass type I membrane protein
Target Information
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 domain-containing receptor family, and the low density lipoprotein receptor family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ21930; FLJ39258; LDLR relative with 11 ligand-binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; mosaic protein LR11; SorLA; SorLA-1; Sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; Sorting protein-related receptor containing LDLR class A repeats
Gene Aliases: C11orf32; gp250; LR11; LRP9; SORL1; SORLA; SorLA-1
UniProt ID: (Human) Q92673
Entrez Gene ID: (Human) 6653
protein targeting to Golgi
protein targeting
protein targeting to lysosome
lipid transport
post-Golgi vesicle-mediated transport
receptor-mediated endocytosis
signal transduction
cholesterol metabolic process
regulation of smooth muscle cell migration
negative regulation of protein binding
negative regulation of protein oligomerization
negative regulation of MAP kinase activity
protein retention in Golgi apparatus
positive regulation of protein catabolic process
negative regulation of neurogenesis
protein maturation
positive regulation of protein exit from endoplasmic reticulum
negative regulation of neuron death
negative regulation of beta-amyloid formation
positive regulation of choline O-acetyltransferase activity
negative regulation of tau-protein kinase activity
positive regulation of ER to Golgi vesicle-mediated transport
positive regulation of early endosome to recycling endosome transport
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of protein localization to early endosome
negative regulation of neurofibrillary tangle assembly
positive regulation of endocytic recycling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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