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Bethyl Laboratories
SOS1 Polyclonal Antibody
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FIGURE: 1 / 1
SOS1 Antibody (A301-890A) in WB
Detection of human SOS1 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-SOS1 antibody (Product # A301-890A) used for WB at 0.04 µg/mL (A) and 1 µg/mL (B) and used for IP at 3 µg/mg lysate. SOS1 was also immunoprecipitated by rabbit anti-SOS1 antibody A301-889A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).
Product Details
A301-890A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1283 and 1333 of Human son of sevenless ortholog 1.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G GINGF; gingival fibromatosis; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; Son of sevenless homolog 1; SOS-1; unnamed protein product
Gene Aliases: GF1; GGF1; GINGF; HGF; NS4; SOS-1; SOS1
UniProt ID: (Human) Q07889
Entrez Gene ID: (Human) 6654
B cell homeostasis
hair follicle development
lymphocyte homeostasis
response to ischemia
heart morphogenesis
cardiac atrium morphogenesis
pericardium morphogenesis
regulation of transcription from RNA polymerase II promoter
signal transduction
epidermal growth factor receptor signaling pathway
small GTPase mediated signal transduction
Ras protein signal transduction
vitellogenesis
axon guidance
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
Schwann cell development
cytokine-mediated signaling pathway
regulation of T cell differentiation in thymus
multicellular organism growth
Fc-epsilon receptor signaling pathway
T cell activation
regulation of cell proliferation
regulation of T cell proliferation
myelination
positive regulation of epidermal growth factor receptor signaling pathway
insulin-like growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
blood vessel morphogenesis
B cell receptor signaling pathway
leukocyte migration
positive regulation of small GTPase mediated signal transduction
palate development
eyelid development in camera-type eye
heart trabecula morphogenesis
midbrain morphogenesis
regulation of pro-B cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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