Invitrogen

SOX11 Polyclonal Antibody

View all (11) SOX11 antibodies

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SOX11 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of SOX11 in human chronic lymphocytic leukemia using a SOX11 polyclonal antibody (Product # PA5-81878). The analysis shows no nuclear positivity in tumor cells as expected.

SOX11 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of SOX11 in human mantle cell lymphoma using a SOX11 polyclonal antibody (Product # PA5-81878). The analysis shows moderate to strong nuclear positivity in tumor cells.

SOX11 Antibody in Western Blot (WB) — Western blot analysis of SOX11 by a SOX11 polyclonal antibody (Product # PA5-81878). Analysis in human cell line SH-SY5Y.

Product Details

Tested Applications

Dilution

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

Western Blot (WB)

0.4 µg/mL

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SOX11

Conjugate

Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Product Specific Information

Immunogen sequence: FMVWSKIERR KIMEQSPDMH NAEISKRLGK RWKMLKDSEK IPFIREAERL RLKHMADYPD YKYRPRKKPK MDPSAKPSAS QSPEKSAAGG GGGSAGGGAG GAKTSKGSSK K

Target Information

This intronless gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: SRY (sex-determining region Y)-box 11; SRY-related HMG-box gene 11; Transcription factor SOX-11

Gene Aliases: MRD27; SOX11

UniProt ID: (Human) P35716

Entrez Gene ID: (Human) 6664

Molecular Function: HMG box transcription factor nucleic acid binding transcription factor

negative regulation of transcription from RNA polymerase II promoter skeletal system development kidney development neural tube formation lens morphogenesis in camera-type eye outflow tract morphogenesis cardiac ventricle formation noradrenergic neuron differentiation transcription from RNA polymerase II promoter translation positive regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression oligodendrocyte development glial cell proliferation neural crest cell development regulation of transforming growth factor beta receptor signaling pathway spinal cord development glial cell development neuron differentiation positive regulation of BMP signaling pathway positive regulation of hippo signaling skeletal muscle cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion sympathetic nervous system development embryonic digestive tract morphogenesis embryonic skeletal system morphogenesis negative regulation of lymphocyte proliferation positive regulation of neurogenesis hard palate development soft palate development limb bud formation negative regulation of glial cell proliferation ventricular septum morphogenesis lung morphogenesis negative regulation of cell death neuroepithelial cell differentiation eyelid development in camera-type eye somite development cornea development in camera-type eye closure of optic fissure signal transduction involved in cell cycle checkpoint positive regulation of stem cell proliferation negative regulation of transcription regulatory region DNA binding positive regulation of lens epithelial cell proliferation

Process(es)

transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity enhancer sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding translation factor activity, RNA binding