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Invitrogen
SOX2 Polyclonal Antibody
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Product Details
PA5-144603
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fish,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The immunogen used to generate this antibody corresponds to zebrafish Sox2.
Conjugate
Form
Liquid
Concentration
1.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY related HMG box 2; SRY-box containing gene 2; Transcription factor Sox-2; transcription factor SOX2
Gene Aliases: cb236; sox2; soxp; wu:fb83g04; wu:fc14d07; zgc:65860; zgc:77389
UniProt ID: (Zebrafish) Q6P0E1
Entrez Gene ID: (Zebrafish) 378723
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
HMG box transcription factor
regulation of transcription, DNA-templated
multicellular organism development
cell proliferation
anatomical structure morphogenesis
epithalamus development
pineal gland development
cell differentiation
forebrain development
regeneration
fin regeneration
eye morphogenesis
inner ear development
positive regulation of sequence-specific DNA binding transcription factor activity
inner ear receptor cell development
otic vesicle development
otic placode development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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