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Invitrogen
SOX4 Polyclonal Antibody
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FIGURE: 1 / 10
SOX4 Antibody (PA5-41442) in ICC/IF
Immunofluorescence analysis of Transcription factor SOX-4 was performed using 70% confluent log phase MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with SOX4 Polyclonal Antibody (Product # PA5-41442) at 1:200 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488... View More
Product Details
PA5-41442
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human SOX4 (aa 38-87).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: STASTGGKAD DPSWCKTPSG HIKRPMNAFM VWSQIERRKI MEQSPDMHNA
Sequence homology: Cow: 100%; Dog: 100%; Goat: 91%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 SOX genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ecotropic viral integration site 16; SRY (sex determining region Y)-box 4; SRY box 4; SRY-box containing gene 4; SRY-related HMG-box gene 4; Transcription factor SOX-4
Gene Aliases: AA682046; EVI16; Sox-4; SOX4
UniProt ID: (Human) Q06945, (Mouse) Q06831
Entrez Gene ID: (Human) 6659, (Mouse) 20677
transcription regulatory region sequence-specific DNA binding
core promoter sequence-specific DNA binding
nucleic acid binding transcription factor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
protein binding
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
HMG box transcription factor
skeletal system development
neural tube formation
pro-B cell differentiation
mitral valve morphogenesis
cardiac ventricle formation
cardiac right ventricle morphogenesis
atrial septum primum morphogenesis
noradrenergic neuron differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
glial cell proliferation
spinal cord development
spinal cord motor neuron differentiation
glial cell development
positive regulation of Wnt signaling pathway
T cell differentiation
endocrine pancreas development
negative regulation of protein ubiquitination
regulation of protein stability
positive regulation of insulin secretion
somatic stem cell population maintenance
ascending aorta morphogenesis
glucose homeostasis
DNA damage response, detection of DNA damage
positive regulation of apoptotic process
positive regulation of translation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of protein export from nucleus
sympathetic nervous system development
protein stabilization
canonical Wnt signaling pathway
limb bud formation
ventricular septum morphogenesis
negative regulation of cell death
neuroepithelial cell differentiation
kidney morphogenesis
cellular response to glucose stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of N-terminal peptidyl-lysine acetylation
response to hypoxia
transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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