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Invitrogen
SOX8 Polyclonal Antibody
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FIGURE: 1 / 4
SOX8 Antibody (PA5-78487) in ICC/IF
SOX8 Polyclonal Antibody detects SOX8 protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SOX8 protein stained by SOX8 Polyclonal Antibody (Product # PA5-78487) diluted at 1:500. Red: Phalloidin, a cytoskeleton marker, diluted at 1:200. Scale bar = 10 µm.
Product Details
PA5-78487
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human SOX8. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.51 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS, human brain
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 8; SRY box 8; Transcription factor SOX-8
Gene Aliases: SOX8
UniProt ID: (Human) P57073
Entrez Gene ID: (Human) 30812
osteoblast differentiation
in utero embryonic development
neural crest cell migration
transcription, DNA-templated
signal transduction
spermatogenesis
peripheral nervous system development
male gonad development
regulation of hormone levels
positive regulation of gliogenesis
positive regulation of osteoblast proliferation
skeletal muscle cell differentiation
negative regulation of apoptotic process
cell fate commitment
fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of photoreceptor cell differentiation
cell maturation
enteric nervous system development
oligodendrocyte differentiation
Sertoli cell development
astrocyte fate commitment
retina development in camera-type eye
retinal rod cell differentiation
adipose tissue development
morphogenesis of a branching epithelium
renal vesicle induction
ureter morphogenesis
metanephric nephron tubule formation
positive regulation of kidney development
positive regulation of branching involved in ureteric bud morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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