Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
SOX8 Antibody (PA5-98170) in WB
Western Blot analysis of SOX8 using a SOX8 Polyclonal antibody (Product # PA5-98170) at a concentration of 5 µg/mL. Positive WB detected in: U87 whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 48 kDa.
Product Details
PA5-98170
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Transcription factor SOX-8 protein (292-386AA)
Conjugate
Form
Liquid
Concentration
2.915 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2812784
Target Information
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 8; SRY box 8; Transcription factor SOX-8
Gene Aliases: SOX8
UniProt ID: (Human) P57073
Entrez Gene ID: (Human) 30812
osteoblast differentiation
in utero embryonic development
neural crest cell migration
transcription, DNA-templated
signal transduction
spermatogenesis
peripheral nervous system development
male gonad development
regulation of hormone levels
positive regulation of gliogenesis
positive regulation of osteoblast proliferation
skeletal muscle cell differentiation
negative regulation of apoptotic process
cell fate commitment
fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of photoreceptor cell differentiation
cell maturation
enteric nervous system development
oligodendrocyte differentiation
Sertoli cell development
astrocyte fate commitment
retina development in camera-type eye
retinal rod cell differentiation
adipose tissue development
morphogenesis of a branching epithelium
renal vesicle induction
ureter morphogenesis
metanephric nephron tubule formation
positive regulation of kidney development
positive regulation of branching involved in ureteric bud morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support