Immunogen sequence: SQRTHIKTEQ LSPSHYSEQQ QHSPQQIAYS PFNLPHYSPS YPPITRSQYD YTDHQNSSSY YSHAAGQGTG LYSTFTYMNP AQRPMYTPIA DTSGVPSIPQ THSPQHWEQP VYTQLTR
SOX9 is a member of the family of SOX (Sry-type high mobility group box) gene that were first identified on the basis of region with high homology to that of Sry (Sex-determining region Y) (1). It is a transcription factor with a high mobility group DNA-binding domain that is expressed in all prechondrocytic and chondrocytic cells during embryonic development in a pattern that close parallels that of the gene for type II collagen (2). Phosphorylation of SOX9 by PKA increases its DNA binding and transcriptional activity (3). SOX9 regulates expression of chondrocyte phenotype related genes (4, 5). IL-1 and TNF-a can cause a marked and rapid decrease in the levels of SOX9 mRNA and/or protein in chondrocytes, thus strongly inhibit the expression of genes for cartilage extracellular matrix proteins (6). The down-regulation of Sox9 may have a crucial role in inhibiting expression of the cartilage phenotype in inflammatory joint diseases.
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Protein Aliases: CMD1; CMPD1; SRA1; SRY (sex determining region Y)-box 9; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 9; SRY-box containing gene 9; SRY-related HMG-box, gene 9; Transcription factor SOX-9
Gene Aliases: 2010306G03Rik; AV220920; CMD1; CMPD1; mKIAA4243; Sox-9; SOX9; SRA1; SRXX2; SRXY10