Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: PYAGVCLAY FTSGFNAAAL DYEADGSTNN GIFQINSRRW CSNLTPNVPN VCRMYCSDLL NPNLKDTVIC AMKITQEPQG LGYWEAWRHH CQGKDLTEWV DGCDF (20-123 aa encoded by B C029867)
SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: acrosomal sperm protein; Cancer/testis antigen 54; CT54; lysozyme C; Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17; Lysozyme-like protein 3; lysozyme-like sperm-specific secretory protein ALLP17; mSLLP1; Sperm acrosome membrane-associated protein 3; sperm c-type lysozyme-like protein; sperm lysozyme like protein 1; Sperm lysozyme-like protein 1; sperm lysozyme-like protein 1 precusor; sperm lyzozyme-like acrosomal protein 1; Sperm protein reactive with antisperm antibodies; Sperm protein reactive with ASA
Gene Aliases: 1700025M08Rik; ALLP17; CT54; LYC3; LYZC; LYZL3; mSLLP1; SLLP1; SPACA3; SPRASA; UNQ424/PRO862
UniProt ID: (Human) Q8IXA5, (Mouse) Q9D9X8
Entrez Gene ID: (Human) 124912, (Mouse) 75622, (Rat) 287557
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support