Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
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Protein Aliases: acrosomal sperm protein; Cancer/testis antigen 54; CT54; lysozyme C; Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17; Lysozyme-like protein 3; lysozyme-like sperm-specific secretory protein ALLP17; mSLLP1; Sperm acrosome membrane-associated protein 3; sperm c-type lysozyme-like protein; sperm lysozyme like protein 1; Sperm lysozyme-like protein 1; sperm lysozyme-like protein 1 precusor; sperm lyzozyme-like acrosomal protein 1; Sperm protein reactive with antisperm antibodies; Sperm protein reactive with ASA
Gene Aliases: 1700025M08Rik; ALLP17; CT54; LYC3; LYZC; LYZL3; mSLLP1; SLLP1; SPACA3; SPRASA; UNQ424/PRO862
UniProt ID: (Human) Q8IXA5, (Mouse) Q9D9X8
Entrez Gene ID: (Human) 124912, (Mouse) 75622, (Rat) 287557
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