The antibody detects endogenous level of total SPAG4 protein.
The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development.
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Protein Aliases: acrosomal protein ACR55; cancer/testis antigen 127; Outer dense fiber-associated protein SPAG4; Sad1 and UNC84 domain containing 4; sperm antigen 4; sperm tail protein; Sperm-associated antigen 4 protein; SUN domain-containing protein 4
Gene Aliases: 1700041K21Rik; CT127; mKIAA4118; MNCb-0953; SPAG4; SUN4